See our recent publication in AAC using ID – ODS!

Model based dose optimization has been shown to aid in predicting drug concentrations. A collaborative work published in November, 2016 in the journal of Antimicrobial Agents and Chemotherapy focused on evaluating the predictive performance of three structurally different voriconazole population pharmacokinetic models. We used published linear, mixed linear and non-linear, and a fully non-linear model for estimations of voriconazole concentrations and calculated measures of bias and precision. While in our work simulations with the linear model were found to be slightly more accurate and similarly precise, the small difference in accuracy is likely negligible from the clinical point of view making all three approaches appropriate for use in a voriconazole TDM program.